This list of African American Historic Places in South Carolina was originally based on a report by the South Carolina Department of Archives & History through its South Carolina African American Heritage Commission. The first edition was originally based on the work of student interns from South Carolina State University or the 2021 update. Some of these sites are on the National Register of Historic Places (NR) as independent sites or as a contributing property (CP) of a historic district. Several of the sites are National Historic Landmarks (NRL). Others have South Carolina historical markers (HM). The citation on historical markers is given in the reference. The location listed is the nearest community to the site. More precise locations are given in the reference. These listings illustrate some of the history and contributions of African Americans in South Carolina.

Abbeville County

Aiken County

Allendale County

Anderson County

Bamberg County

Barnwell County

Beaufort County

Berkeley County

Calhoun County

Charleston County

Cherokee County

Chester County

Chesterfield County

Clarendon County

Colleton County, South Carolina

Darlington County

Dillon County

Dorchester County

Edgefield County

Fairfield County

Florence County

Georgetown County

Greenville County

Greenwood County

Hampton County

Horry County

Jasper County

Kershaw County

Lancaster County

Laurens County

Lee County

Lexington County

Marion County

Marlboro County

Newberry County

Oconee County

Orangeburg County

Pickens County

Richland County

Saluda County

Spartanburg County

Sumter County

Union County

Williamsburg County

York County