Lisle-en-Barrois (, literally Lisle in Barrois) is a commune in the Meuse department in Grand Est in north-eastern France. It is part of the Bar-le-Duc arrondissement, and is approximately 17 km north of Bar-le-Duc itself. As of 2021, the population of Lisle-en-Barrois stood at just 30 residents. Like many rural communes in France, its population has seen a gradual decline over the years due to urban migration and demographic changes.