The Liquid Propulsion Systems Centre (LPSC), Thiruvananthapuram is a research and development centre functioning under Indian Space Research Organisation (ISRO). It has two units located at Valiamala, in Thiruvananthapuram of Kerala, and Bengaluru of Karnataka. LPSC is augmented by ISRO Propulsion Complex at Mahendragiri of Tamil Nadu. LPSC is engaged in development of liquid and cryogenic propulsion stages for launch vehicles and auxiliary propulsion systems for both launch vehicles and satellites. Activities related to liquid propulsion stages, cryogenic propulsion stages and control systems for launch vehicles and spacecraft is done at Thiruvananthapuram. Precision fabrication facilities, development of transducers and integration of satellite propulsion systems are carried out at Bangalore. The developmental and flight tests along with assembly and integration are done at ISRO Propulsion Complex, Mahendragiri in Tamil Nadu. The development of liquid propellant stages for PSLV, control systems for SLV-3, ASLV, PSLV and GSLV, satellite propulsion systems including those for INSAT and IRS and production of pressure transducers are done by the LPSC for India. The LPSC has developed indigenous cryogenic upper stage for Geosynchronous Satellite Launch Vehicle (GSLV) which was successfully test fired by ISRO on 4 August 2007. LPSC's current director is Dr. V Narayanan. He succeeded Mr. S Somnath in January 2018 after which Shri S Somnath was appointed as Director of VSSC.

LPSC Trivandrum

This unit serves as LPSC headquarters, and is involved in research and development of Earth-storable and cryogenic propulsion for launch vehicles. It delivers engines, stages, associated control systems and components for launch vehicle and spacecraft. The main activities carried out at Valiamala include:

LPSC Bangalore

This unit caters predominantly to propulsion requirements of satellite programmes of ISRO apart from development of indigenous sensors and transducers. The activities that are carried out here include:

IPRC Mahendragiri

On 1 February 2014, this unit was renamed as Indian Space Research Organisation (ISRO) Propulsion Complex and was also made an autonomous department under ISRO. The Mahendragiri unit was previously functioning under LPSC in Valiamala. The main activities carried out at here are: