Lansford Spence (born 15 December 1982) is a Jamaican sprinter. Together with Sanjay Ayre, Brandon Simpson and Davian Clarke he won a bronze medal in 4 x 400 metres relay at the 2005 World Championships in Athletics. He also competed in the individual contest, but was knocked out in the semi-final. In 2006 the relay team won another bronze medal at the Commonwealth Games. He won a Commonwealth Games Silver medal in the 200m in 2010. He was one of five athletes (along with Yohan Blake, Marvin Anderson, Allodin Fothergill and Sheri-Ann Brooks) who failed their doping tests at the 2009 Jamaican National Championships. All five tested positive for banned stimulant methylxanthine. Spence received a three-month doping ban for the infraction.

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