The Kukpuk River (Iñupiaq: Kuukpak) is a stream, about 125 mi long, in the western North Slope Borough of the U.S. state of Alaska. It flows generally west from the De Long Mountains across the Lisburne Peninsula to Marryat Inlet on the Chukchi Sea. The river mouth is about 12 mi northeast of Point Hope. The Inuit name "Kuukpak" means "big river". A late 19th-century variant was "Kookpuk".