The Journal of Computational Biology is a monthly peer-reviewed scientific journal covering computational biology and bioinformatics. It was established in 1994 and is published by Mary Ann Liebert The editors-in-chief are Sorin Istrail (Brown University) and Michael S. Waterman (University of Southern California). According to the Journal Citation Reports, the journal has a 2021 impact factor of 1.549. Since 1997, authors of accepted proceedings papers at the Research in Computational Molecular Biology conference have been invited to submit a revised version to a special issue of the journal.