José Guillermo Santiago Guzmán (September 4, 1928 – October 9, 2018), better known by the nickname "Pantalones", was a Puerto Rican professional baseball pitcher who played in Major League Baseball between 1954 and 1956 for the Cleveland Indians (–) and Kansas City Athletics. In the Negro leagues, he played for the New York Cubans from 1947 to 1948.

Playing career

Born in Coamo, he was listed at 5 ft tall and 175 lb, he batted and threw right-handed. During his three MLB trials, Santiago posted a 3–2 record with 29 strikeouts and a 4.66 ERA in 27 appearances, including five starts and 56 innings of work, allowing 67 hits and 33 bases on balls. His entire pro career encompassed 13 years, 1947–1959, with two years in the Negro leagues and 11 in minor league baseball. In 2003, Santiago was inducted into the Caribbean Baseball Hall of Fame.

After baseball

In the 1970s, Santiago became a boxing promoter in Puerto Rico. A believer in Puerto Rican Independence, Santiago, like his friend Fufi Santori, owned a technically possible, Puerto Rican passport, in his case numbered #001261, since 1997.