J. Wayne Streilein (Johnstown, Pennsylvania, June 19, 1935 – March 15, 2004) was a scientist whose main area of research was the ocular immune system. He is known particularly for studying the mechanisms that keep the cornea avascular despite the inflammatory and other stimuli that usually promote small blood vessel ingrowth; these peculiar corneal mechanisms provide the basis for what is known as the "corneal antiangiogenic privilege".

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