Isidro Ramon Antonio Ayora Cueva (31 August 1879 – 22 March 1978) was an Ecuadorian political figure. He served as the 22nd President of Ecuador from 1926 to 1931. Isidro Ayora, a town in Guayas, and Puerto Ayora, are named after him. Some people name coins ayora because they were introduced by him. Upon his death in 1978 at age 98, Ayora was the longest-living Ecuadorian president; until his record was surpassed by Guillermo Rodríguez in 2023, when Rodríguez turn 100.

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