The** Regeneron International Science and Engineering Fair** (ISEF) is an annual science fair in the United States. It is owned and administered by the Society for Science, a 501(c)(3) non-profit organization based in Washington, D.C. Each May, more than 1800 students from roughly 75 countries and territories compete in the fair for scholarships, tuition grants, internships, scientific field trips and the grand prizes, including one $75,000 and two $50,000 college scholarships. All prizes together amount to over $8,000,000. Two major awards ceremonies are the Special Awards Organization Presentation (which now includes the Government Awards Presentations) and the Grand Awards Ceremony. The International Science and Engineering Fair was founded in 1950 by Science Service (now the Society for Science) and was sponsored by Intel from 1997 to 2019. Regeneron Pharmaceuticals became the title sponsor for ISEF in 2020, but the event was cancelled that year and replaced with an online version due to the COVID-19 pandemic. The 2021 ISEF was a fully virtual event while 2022 was held online and in-person in Atlanta, GA, and 2023 was in person in Dallas, TX. The 2024 ISEF was held in person in Los Angeles, CA. The 2025 ISEF will be held in Columbus, OH.

Notable alumni

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Contestants and competition

Contestants are selected from regional, district, and state ISEF affiliated fairs. These fairs usually encompass multiple states or entire regions of a country. The regional fair committee is responsible for managing the fair when their city hosts the event. Individual science projects and team science projects both compete for prizes. Teams are composed of two to as many as four high school students (grades 9–12). In addition to the judging of projects and an open session for the public to view them, there is time set aside for students to experience the host city with tours and activities. A significant component of the program is social, as students interact with each other during mixers and ceremonies. Throughout much of the week, various seminars are also held for students, mentors and teachers. Projects and judging are divided into 22 subject categories as follows:

Prizes and honors

ISEF used to hold a "People's Choice Award" to allow the public to vote for its favorite entries. Since 2001, MIT's Lincoln Laboratory has named asteroids after ISEF winners as part of the Ceres Connection. Multiple organizations sponsor 'special awards' with their own distinct criteria. These organizations include the National Security Agency, Association for Computing Machinery, IEEE Foundation, and Patent and Trademark Office Society.

Finalist Medal

The Regeneron ISEF Finalist Medal is given to about 1800 students from 75 countries each year, which are participating at the Regeneron International Science and Engineering Fair, which is owned and administered by the Society for Science, a 501(c)(3) non-profit organization based in Washington, D.C. Each year about 7 million students participate in different regional, district, and state ISEF affiliated fairs. Some of the winners of these affiliated fairs, which exist in over 75 countries, get the chance to take part at the Regeneron ISEF as a finalist, and each of them is awarded Regeneron ISEF Finalist Medal. In 2013 there were 1611 finalists at the Intel ISEF in Phoenix, Arizona. The medal has a diameter of 48 mm and is golden galvanized. The obverse shows the official logo of the Regeneron ISEF, the reverse shows the year of participation and the location of that year's Regeneron ISEF. The ribbon bar is blue with a width of 40 mm and has a golden romanic 1 in the middle.

Top prize winners

When Intel began sponsoring ISEF in 1997, the Grand Awards were replaced with the Intel Foundation Young Scientist Awards, awarded to the top three projects. In 2010, the top award was renamed for Intel co-founder Gordon E. Moore.