Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements.

Mechanism of action

When ingested, inositol nicotinate breaks down into inositol and niacin. The niacin component helps widen blood vessels (vasodilation), lowers blood lipid levels (including cholesterol), and inhibits a protein involved in blood clotting.

Uses

Inositol nicotinate is used to treat blood circulation problems, including: Some research shows it can improve symptoms of Raynaud's phenomenon over several weeks. However, its effectiveness in treating other conditions like: remains unclear, with studies producing mixed results. Other proposed uses, such as for: have insufficient supporting evidence.

Side effects

Inositol nicotinate is generally safe when taken by mouth, but possible side effects include: It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin.

Precautions

Inositol nicotinate should be used with caution in individuals with certain conditions: