Indian Mission Church is a historic Methodist church located in Millsboro, Sussex County, Delaware. It was built in 1921, and is a one-story, wood-frame building covered with clapboard siding and in the Late Gothic Revival style. It features a two-story hipped roof tower and lancet windows. The congregation was organized in 1881 from the Harmony Church after the strongly Native American families of the Nanticoke community separated after the hiring of an African American minister. It was added to the National Register of Historic Places in 1979.