Hydroxymethylglutaryl-CoA reductase (NADPH)

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In enzymology, a hydroxymethylglutaryl-CoA reductase (NADPH) is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NADP+, whereas its 3 products are (S)-3-hydroxy-3-methylglutaryl-CoA, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in biosynthesis of steroids including cholesterol. The statin class of anticholesterol drugs act through inhibiting this enzyme.

Nomenclature

The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase (CoA-acylating). Other names in common use include:

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , and.

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