In enzymology, a hydrogen:quinone oxidoreductase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are H2 and quinone, whereas its product is quinol. The quinone can be menaquinone, ubiquinone, demethylmenaquinone or methionaquinone. This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with a quinone or similar compound as acceptor. The systematic name of this enzyme class is hydrogen:quinone oxidoreductase. Other names in common use include hydrogen-ubiquinone oxidoreductase, hydrogen:menaquinone oxidoreductase, membrane-bound hydrogenase, and quinone-reactive Ni/Fe-hydrogenase.