Humphreys Station (formerly, Humphreys) is an unincorporated community in Fresno County, California. It is located 23 mi northeast of Fresno. The name honors pioneer John W. Humphreys. John and his brother Miles Humphreys opened a store at the site after the Civil War. The business catered to stage travelers and to lumber workers on the Tollhouse Road, and was an unofficial passenger drop-off point for the Butterfield Overland Mail. Originally known as Humphreys Station, the site often became known as Humphrey Station after a restaurant of that name opened on the site in 1920. A one-room schoolhouse operated at Humphreys Station until 1926.