HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms. DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution, having diverged from DRB1 around 4 million years ago. The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.

Alleles

Associated diseases

DR52 serotype is positively associated with systemic sclerosis, inflammatory myopathies, inclusion body myositis, DRB3*01 is positively associated with sarcoidosis, Grave's Disease, pulmonary sarcoidosis, DRB301:01:DRB103:01 is linked to Lofgren's syndrome DRB3*02:02 is also linked to Grave's disease, serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, acute necrotizing encephalopathy DRB3*03:01 is weakly associated with anticardiolipin antibodies in SLE DRB303:01:DRB113:02 may be associated with Crohn's disease

DRB1 linkage

HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups: HLA-DR3 - DRB1*03 HLA-DR5 - HLA-DR6 - Rarely HLA-DR8 - DRB1*08 HLA-DR52 - Sjögren syndrome