Harlem Avenue is a major north–south street located in Chicago and its west, southwest, and northwest suburbs. It stretches from Glenview Road in Glenview to the intersection of East South Street and South Drecksler Road in Peotone, where it diverges into Illinois Route 50. At 54.1 mi, it is the third-longest street in the United States, after Telegraph Road in southeastern Michigan and O Street in Nebraska. For most of its length, it carries Illinois Route 43. An express bus service from Pace Pulse is currently being planned for the portion of the street between 95th Street and North Avenue, serving primarily the southern and western suburbs.

Communities served

From north to south:

Major intersections

Major transit connections

As one of the most important thoroughfares in Chicagoland outside of Downtown Chicago, Harlem Avenue offers a number of transit connections to the Chicago Loop and points west. Two of Amtrak's secondary Chicagoland stations are also located along Harlem Avenue, serving the two most popular Midwest passenger services (Hiawatha between Chicago and Milwaukee and Lincoln between Chicago and St. Louis) as well as three long-distance routes. Listed from south to north: