The Golden Globe Award for Best Actor in a Motion Picture – Musical or Comedy is a Golden Globe Award presented annually by the Hollywood Foreign Press Association. It is given in honor of an actor who has delivered an outstanding performance in a leading role in a musical or comedy film. Previously, there was a single award for "Best Actor in a Motion Picture", but the creation of the category in 1951 allowed for recognition of it and the Best Actor – Drama. The formal title has varied since its inception. In 2006, it was officially called: "Best Performance by an Actor in a Motion Picture – Musical or Comedy". , the wording is "Best Actor in a Motion Picture – Musical or Comedy".

Winners and nominees

1950s

1960s

1970s

1980s

1990s

2000s

2010s

2020s

Multiple wins and nominations

Multiple wins

Multiple nominations

Multiple character nominations

Winners are in bold.