The Gillis-Grier House is a historic home located at Salisbury, Wicomico County, Maryland, United States. It is a 2 1/2-story Queen Anne style frame house built in 1887 by James Cannon. The house has gable-front elevations on three sides, a three-story octagonal tower, and a shorter 2 1/2-story service wing. Also on the property is a frame 1 1/2-story stable, now used as a garage. It is one of the dwellings that define Salisbury's Newtown neighborhood and named after the two inter-related families that held title to the property between 1896 and 1975. The Gillis-Grier House was listed on the National Register of Historic Places in 1972.