George Ghica (, ; 3 March 1600 – 2 November 1664) founder of the Ghica family, was the prince of Moldavia from 1658 to 1659 and the prince of Wallachia from 1659 to 1660. While in Istanbul, he became close friends with the Grand Vizier Köprülü Mehmed Pasha and helped him on to high positions. As Prince of Wallachia he moved the capital from Târgoviște to Bucharest. From him are descended the numerous branches of the family which became notable in the history of Moldavia and Wallachia. His son was Grigore I Ghica.