The General Secretary of the TUC is the chief permanent officer of the Trades Union Congress, and a major figurehead in the trade union movement in the United Kingdom. The Secretary is responsible for the effective operation of the TUC and for leading implementation of policies set by the annual Congress and the organisation's General Council. They also serve as the TUC's chief representative, both with the public and with other organisations. The position was formed in 1921, when the Parliamentary Committee of the TUC became the General Council. The position of Secretary has been a permanent, full-time position in the TUC since 1904. Before that, the Secretary was elected annually at Congress. Between January 2013 and December 2022, the incumbent position was held by Frances O'Grady, the first woman to hold the post. O'Grady was succeeded by the current General Secretary, Paul Nowak – the Deputy General Secretary during O'Grady's leadership – on 29 December 2022.

Secretaries of the Parliamentary Committee of the TUC

General Secretaries of the TUC

{{legend|#E6E6AA|Denotes Acting General Secretary}}

Deputy General Secretaries of the TUC

Assistant General Secretaries of the TUC