François de Bourbon, Count of Enghien (23 September 1519 – 23 February 1546) was a French prince du sang from the House of Bourbon-Vendôme, a cadet branch of the House of Bourbon (itself a cadet branch of the Capetian dynasty). He was the son of Charles de Bourbon, Duke of Vendôme and Françoise d'Alençon. Given command of the French army in Italy by Francis I of France during the Italian War of 1542, he was the French commander at the successful Franco-Ottoman Siege of Nice in 1543, and he led it to victory at the Battle of Ceresole in a year later in 1544. His early death at the age of 26 was caused by an accident – specifically by the falling of a heavy chest – in the castle La Roche-Guyon. He was succeeded as Count of Enghien by his younger brother John (Jean), who was also the Count of Soissons.

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