Euphronia Presbyterian Church is a historic Presbyterian church and national historic district located at 3800 Steel Bridge Road near Sanford, Lee County, North Carolina. It was built in 1886, and is a two-story frame building with weatherboard siding and a gable-fronted nave form. It features a two-tier belfry rising from the roof ridge. Also on the property is a contributing church cemetery. It was listed on the National Register of Historic Places in 1994.