The Edwards River is a 73.7 mi tributary of the Mississippi River in northwestern Illinois in the United States. It rises 3 mi west of Kewanee in southeastern Henry County and flows generally westwardly into Mercer County, where it joins the Mississippi 2 mi southeast of New Boston. In Henry County it collects the South Edwards River, which flows past Bishop Hill. The river was once home to a grain mill near Andover, Illinois. Several sections of the Edwards River's course have been straightened and channelized.