Edward Stafford, 4th Baron Stafford (1572 – 16 September 1625), was the son of Edward Stafford, 3rd Baron Stafford, and Mary Stanley, daughter of Edward Stanley, 3rd Earl of Derby, and Dorothy Howard. He became 4th Baron Stafford on the death of his father in 1603. He married Isabel Forster, the daughter of Thomas Forster of Tong, Shropshire. Isabel was reported to be a family chambermaid in a letter to the Earl of Leicester which includes "My Lorde Stafford's son is basely married to his mother's chambermaid." Edward Stafford continued on with his father's patronage of the Lord Stafford's Company, a travelling group of players, who were active until at least 1617.

Death and succession

Stafford had one son, Edward (1602 – 6 April 1621). This son married Ann Wilford, daughter of James Wilford, Newman Hall, Quendon, Essex, and had two children: