The Dugdemona River (pronounced dug-duh-mona) is a 129 mi tributary of the Little River in north-central Louisiana in the United States. Via the Little, Ouachita and Red rivers, it is part of the watershed of the Mississippi River. The Dugdemona River rises west of Simsboro in western Lincoln Parish, and flows generally southeastwardly through Bienville, Jackson, Winn and Grant parishes, through a portion of the Kisatchie National Forest. It joins Castor Creek to form the Little River about 3 mi northeast of Georgetown. A short tributary known as the Little Dugdemona River flows southwestwardly through Jackson and Bienville parishes. At Joyce, LA, the river has a mean annual discharge of 835 cubic feet per second.

Variant names and spellings

According to the Geographic Names Information System, the Dugdemona River has also been known historically as: