Don Bosco Higher Secondary School is a private, English-medium, co-educational school in Irinjalakuda, Kerala, India. It was established in March 1962 on the invitation of the late Bishop of Thrissur, George Alappatt. It began as an English-medium and a Malayalam-medium school and the Government sanctioned it as an unaided but recognised school on 6 May 1962. The Malayalam-medium section was discontinued later. A boarding section was started on 2 January 1963 but was closed later on. In 1987, an indoor stadium was built to commemorate the Silver Jubilee of the Institution.

Notable alumni