Prince Dominik Mikołaj Radziwiłł (1643–1697) was a Polish–Lithuanian nobleman (szlachcic) and politician. He was son of Court and Grand Marshal Aleksander Ludwik Radziwiłł and Princess Lucricia Marie Strozzi. He married Anna Marianna Połubienska on 11 October 1660, and in 1692 the daughter of Grand Marshal and Hetman Jerzy Sebastian Lubomirski, Anna Krystyna Lubomirska. He was Ordynat of Kleck, Deputy Chancellor of Lithuania since 1681 and Grand Chancellor of Lithuania since 1690. He was also Starost of Lida, Radom, Pińsk, Tuchola and Gniew. Through his son Jan, he was the great-grandfather of Michał Hieronim Radziwiłł.