The Dominguez Canyon Wilderness is a U.S. Wilderness Area located southeast of Grand Junction in western Colorado. The 66280 acre wilderness area established in 2009, the largest BLM roadless area in the state of Colorado, includes two major canyon systems that drain the northeastern corner of the Uncompahgre Plateau. The Wilderness Area is a portion of the larger Dominguez-Escalante National Conservation Area, 209610 acre in size.