Cultural interest fraternities and sororities, in the North American student fraternity and sorority system, refer to general, social organizations oriented to students having a special interest in a culture or cultural identity. Although racial and religious restrictions have long since been abolished in all North American Interfraternity Conference and National Panhellenic Conference organizations, their memberships nationally remain predominantly Caucasian, and National Pan-Hellenic Council memberships largely African American. The new generation of cultural interest organizations has arisen to serve the interests of communities whose numbers in the traditional Greek system are historically small and dispersed. Following is a list of national cultural interest fraternities and sororities.

African American

African-American fraternities and sororities are social organizations that predominantly recruit Black college students and provide a network that includes both undergraduate and alumni members. These organizations were typically founded by Black American undergraduate students, faculty, and leaders at various institutions in the United States.

Armenian

Asian American

There are over sixty Asian American interest Greek-lettered organizations, many of which are overseen by the National APIDA Panhellenic Association.

Buddhist

Christian

While most of the traditional women's fraternities or sororities were founded decades before the start of the 20th century, the first ever specifically Christian-themed Greek letter organization formed was the Kappa Phi Club, founded in Kansas in 1916. The three largest Christian fraternities established in the early part of the 20th century are Beta Sigma Psi, Alpha Gamma Omega, and Sigma Theta Epsilon; all are still active.

Italian-American

Feminism

Jewish

Latino

Latino Greek-letter organizations, in the North American student fraternity and sorority system, refer to general or social organizations oriented to students having a special interest in Latino culture and identity. The first known Latino fraternal organization was Alpha Zeta fraternity, established in 1889 at Cornell University.

LGBTQ

LGBTQ fraternities and sororities have existed since the 1980s, with Delta Phi Upsilon being established in 1985 and Delta Lambda Phi in 1986. These groups are intended to provide members with access to Greek life without fear of homophobic reprisal or behavior by fellow members, resulting from a history of homophobia within longer-established organizations.

Multicultural

These organizations do not identify with a specific cultural identity. Some may fall under associations that cater to specific cultural backgrounds, however, the organization itself refers to itself as Multicultural.

Muslim

Native American

Persian

South Asian