The Comite River is a right-bank tributary of the Amite River, with a confluence near the city of Denham Springs, east of Baton Rouge, Louisiana. The river is 56.1 mi long. Its drainage basin comprises about 348 sqmi, and includes portions of Wilkinson and Amite Counties in Mississippi, and East Feliciana and East Baton Rouge Parishes in Louisiana. The river's source lies in the hills of the East and West Feliciana Parishes, and empties into the Amite River just north of U.S. Route 190 (Florida Blvd) near the eastern boundary of Baton Rouge.

Flooding

Following heavy rainfall, the water drains into the river. During flood events, homes in outlying areas east of Baton Rouge can become flooded. The flood of record saw floodwaters cover Greenwell Springs Road.