Colonial Hotel, also known as Inn at Wise Courthouse, is a historic hotel building located in Wise, Wise County, Virginia. It was built in 1910, and is a 2 1/2-story, roughly U-shaped building with a hipped roof. It is constructed of brick, painted white, and is in the Colonial Revival style. It features an angled entrance sheltered by a pedimented colossal Ionic order portico with paired round columns flanked by paneled square columns. It was listed on the National Register of Historic Places in 1991.