Cocalico Creek is a 27.2 mi tributary of the Conestoga River in Lebanon and Lancaster counties in Pennsylvania in the United States. The source is at an elevation of 1320 ft near Stricklerstown in Millcreek Township, Lebanon County. The mouth is the confluence with the Conestoga River at an elevation of 278 ft at Talmage in West Earl Township, Lancaster County. The name of the creek comes from the Lenape, meaning "snake dens". It comes from the Lenape word Gookcalicunk (pronounced "Gook Cal-eek Unk), which means "Snake Sleep Place" in English. The Lenape considered modern East Cocalico, West Cocalico, Clay, Warwick, Elizabeth, and Penn townships in Lancaster County, Mill Creek Township in Lebanon County, and the Middle Creek Wildlife Management Area as part of Gookcalicunk. Cocalico Creek flows south for 10 mi, then southwest 16 mi. The Cocalico Creek watershed has a total area of 140 sqmi and is part of the larger Chesapeake Bay drainage basin via the Susquehanna River.

Tributaries