The Clark–Lester House is a historic home located at Lancaster in Erie County, New York. It is a Queen Anne style dwelling constructed about 1891. It was home to noted psychology professor Olive Lester, who lived here for most of her adult life until May 1996. She was the first woman chair of any of the departments at the University at Buffalo. It is now operated as a bed and breakfast. It was listed on the National Register of Historic Places in 1999. It is located in the Broadway Historic District.