Charles Edwin Johnson (June 15, 1936 – January 7, 2024) was an American civil servant. He had served as Acting United States Secretary of Health and Human Services from January to April 2009 during the Obama presidency. Johnson was appointed by then President George W. Bush in 2005 as Assistant Secretary for Budget, Technology, and Finance. He was a public accountant for 31 years prior to joining the department. Johnson died from blood cancer on January 7, 2024, at the age of 87.