Centreville Historic District is a national historic district at Centreville, Queen Anne's County, Maryland, United States. It contains an exceptional collection of 18th, 19th, and 20th century buildings chronicling the architectural development of an Eastern Shore of Maryland community. Among Centreville's residential, commercial, and ecclesiastical buildings are representative examples of the various architectural types and styles which characterized towns in the region during the period. It was added to the National Register of Historic Places in 2004.