The Central Ozarks Conference is a high school athletic conference represented by 14 schools in the southwest portion of Missouri. All schools are in the Ozarks state region. The Central Ozark Conference offers championships for girls in Basketball, Cross Country, Golf, Soccer, Softball, Swimming & Diving, Tennis, Track & Field, Volleyball, and Wrestling. The Central Ozark Conference offers championships for boys Baseball, Basketball, Cross Country, Football, Golf, Soccer, Swimming & Diving, Tennis, Track & Field, and Wrestling.

List of member schools

With the addition of the four former Ozark Conference schools for the 2024–25 school year, the conference is now split into two, seven-team divisions.

Membership history

Carl Junction joined the Central Ozark Conference in July 2016 after three decades in the Big 8 Conference (Missouri). Joplin High School joined the Central Ozarks Conference in July 2018. Joplin moved from the Ozark Conference. The Central Ozark Conference Small division disbanded after the 2017-18 school year. The remaining schools, except Bolivar High School, will join the Big 8 Conference (Missouri). Bolivar applied to join the Ozark Conference in late December, but was rejected. They went independent for three seasons and were admitted into the Ozark Conference in July 2021 on a second attempt to join, replacing Central High School(Springfield), who went independent. On October 11, 2023, Carl Junction and Branson announced they would be joining the new Ozark Mountain Conference for the 2024-25 school year. Shortly after, the conference elected to send invitations to Kickapoo and Glendale which they accepted and are to start playing in the conference in the 2024-25 school year. Because of the accepted invitations from Kickapoo and Glendale along with Hillcrest, West Plains, and Bolivar leaving for the new Ozark Mountain conference, the conference sent invitations to the remaining Ozark Conference schools, of which Central, Lebanon, Parkview, and Waynesville accepted as full members.