Carlos Antonio Mendoza Soto (31 October 1856, in Panama City – 13 February 1916) was a Panamanian politician who served in 1908 and 1909 as the second presidential designate in the government of José Domingo de Obaldía. After the death of the first presidential designate José Agustín Arango in 1909 he was first in line to the presidency. In that capacity, Mendoza became President of Panama from 1 March 1910 to 1 October 1910. He belonged to the Liberal Party. Mendoza was elected as the third presidential designate by the National Assembly for the 1904–1906 term.