Cape Girardeau Commercial Historic District is a national historic district located in Cape Girardeau, Missouri. In 2000, the area listed was 1.6 acre and included 17 contributing buildings. In a first increase, an 1891 contributing building at 101 North Main Street was added. The building was designed by Jerome B. Legg and Henry Ossenkop in the Romanesque style. In a second increase, three contributing buildings dating from 1870 were added. The two increases added 0.9 acre each to the original listed area. It was listed on the National Register of Historic Places in 2000 with boundary increases in 2007 and 2008.