Calcium diglutamate, sometimes abbreviated CDG and also called calcium biglutamate, is a compound with formula Ca(C5H8NO4)2. It is a calcium acid salt of glutamic acid. CDG is a flavor enhancer (E number E623)—it is the calcium analog of monosodium glutamate (MSG). Because the glutamate is the actual flavor-enhancer, CDG has the same flavor-enhancing properties as MSG but without the increased sodium content. Notably, only the L isomer is used in flavouring as D -glutamate does not have an umami/savoury flavour. As a soluble source of calcium ions, this chemical is also used as a first-aid treatment for exposure to hydrofluoric acid.

Synthesis and reactions

Calcium di-glutamate can be prepared by reacting calcium carbonate with two molar equivalents of glutamic acid: Concentration of the solution to a syrup under reduced pressure, followed by gradual crystallisation, affords the monohydrate. Structurally, the glutamate anion is zwitterionic, with the amino group protonated (pKa = 9.47) and both carboxylic-acid groups (pKa = 2.10, 4.07) in their deprotonated carboxylate form. Calcium di- L -glutamate can be used to prepare other glutamates through metathesis with a soluble sulfate, carbonate or hydroxide salt. For example, manganese(II) di- L -glutamate can be prepared through metathesis with manganese(II) sulphate: