The Cabinet of the Republic of Kenya is made up of the elected President and Deputy President, together with the appointed Attorney General, and Cabinet Secretaries. Cabinet Secretaries are nominated by the President and approved by Parliament, following vetting procedure. Once approved, they can be reshuffled at the President's discretion. Article 152 of the Constitution of Kenya sets the procedure for appointment confirmation and dismissal of cabinet secretaries. It provides that there shall be a minimum of 14 and a maximum of 22 cabinet secretaries. A Cabinet Secretary is not a member of the Kenyan Parliament and has to be vetted by a parliamentary committee before their appointment.

Cabinet of William Ruto (as of November 2024)

The President of Kenya William Ruto C.G.H. appointed his first cabinet in September 2022. On 11 July 2024, following sustained pressure on the government through the Kenya Finance Bill protests, Ruto dismissed his entire cabinet, with the exception of Prime Cabinet Secretary and Foreign and Diaspora Affairs Cabinet Secretary (Minister) Musalia Mudavadi. All ministries became vacant pending appointment of new nominees by the Ruto and vetting by parliament. On 20 July 2024, Ruto nominated the Cabinet Secretaries, six of whom served in the previous cabinet, who were then vetted and approved by Parliament, despite protests from a section of Kenyans on returning 6 Cabinet Secretaries from the previous Cabinet formation. On 1 November 2024, Kithure Kindiki was sworn in as the 3rd Deputy President of the Republic of Kenya following the impeachment by the National Assembly on 8 October 2024 and Senate on 17 October 2024 of Rigathi Gachagua as Deputy President. Kindiki resigned as Cabinet Secretary for Interior and National Administration to take up the position of Deputy President following the High Court lifting conservatory orders blocking the swearing in. Musalia Mudavadi is currently the Acting Cabinet Secretary for Interior and National Administration having been appointed by President William Ruto on 31 October 2024.