Brookville Presbyterian Church and Manse is a historic Presbyterian church located at White and Main Streets in Brookville, Jefferson County, Pennsylvania, United States. The church was built in 1904–1905, and is a Richardsonian Romanesque-style building built of Hummelstown brownstone. It features two entrances, each set in a loggia, and a square bell tower. The interior is designed in the Akron plan. The manse was built in 1890, and is a brick Second Empire-style dwelling. It features two, 2-story bay windows; a mansard roof; and an open porch. It was added to the National Register of Historic Places in 1982. It is located in the Brookville Historic District.