The Bolton River is a river in the Hudson Bay drainage basin in Census Division No. 22 - Thompson-North Central, Northern Region, Manitoba, Canada. It is about 115 km long and begins at Musketasonan Lake, about 20 km south of Molson Lake, at an elevation of 249 m. It flows northeast through Little Bolton Lake at an elevation of 224 m, Rushforth Lake at an elevation of 218 m, Bolton Lake at an elevation of 212 m, where it takes in the right tributary Nikik River, and Kakwusis Lake at an elevation of 208 m. The river continues northeast over the twin Kasukwapiskechewak Rapids, then over the twin Kakwu Rapids, and empties into Aswapiswanan Lake at an elevation of 186 m, about 60 km west southwest of the community of Gods Lake Narrows. The Bolton River's waters eventually flow into Gods Lake, and via the Gods River and the Hayes River into Hudson Bay.