The Blanco River is a river of Naguabo, Puerto Rico. This river begins at the junction of the Cubuy River, the Icacos River and the Prieto River in the Luquillo Forest Reserve at an approximate elevation of 558 ft above sea level. It is approximately 8.5 mi in length, from its origin until its discharge into the east of Puerto Rico in Río barrio in the municipality of Naguabo. It runs from north to southeast.