Bisacquino (Sicilian: Busacchinu) is a town and comune in the Metropolitan City of Palermo in Sicily, Italy. It is located 82 km from Agrigento and has approximately 4,500 inhabitants. The small town rises on an inner hill zone and is 700 m above sea-level. The economy is based on agriculture and products are sold in abundance in the main town including cereals, olives, vegetables, almonds, hazel nuts and wine-grapes. Sheep breeding is also active in Bisacquino.

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In the Everybody Loves Raymond episode "Mia Famiglia", "Zia (aunt) Sarina" hails from Bisacquino.