Alfiano Natta is a comune (municipality) in the province of Alessandria in the Italian region Piedmont, located about 40 km east of Turin and about 35 km northwest of Alessandria. Alfiano Natta borders the following municipalities: Calliano, Castelletto Merli, Moncalvo, Odalengo Piccolo, Penango, Tonco, and Villadeati. Alfiano Natta is a major contributor to the economy of the province of Alessandria. Wine from the comune is sold in Italy and exported. The area is also known for its landscapes and clean air.