In the Roman Empire, it was sometimes referred to as year 853 ab urbe condita, i.e., 853 years since the founding of Rome in 753 B.C. The denomination AD 100 for this year has been used since the Early Middle Ages, when the Anno Domini calendar era became the prevalent method in Europe for naming years. This year saw Pacores, the last king of the Indo-Parthian kingdom, ascend to the throne. In the Americas, the Moche culture developed around this time, and Teotihuacan, a major city at the centre of modern-day Mexico, reached a population of around 60,000–80,000.

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