The meridian 53° west of Greenwich is a line of longitude that extends from the North Pole across the Arctic Ocean, Greenland, Newfoundland, the Atlantic Ocean, South America, the Southern Ocean, and Antarctica to the South Pole. In Antarctica, the meridian defines the eastern limit of Chile's territorial claim and passes through the British and Argentinian claims - the three claims overlap. It also defines the western limit of Brazil's unofficial claim. The 53rd meridian west forms a great circle with the 127th meridian east.

From Pole to Pole

Starting at the North Pole and heading south to the South Pole, the 53rd meridian west passes through: ! scope="col" width="120" | Co-ordinates ! scope="col" width="120" | Country, territory or sea ! scope="col" | Notes ! scope="row" style="background:#b0e0e6;" | Arctic Ocean ! scope="row" style="background:#b0e0e6;" | Lincoln Sea ! scope="row" | 🇬🇱 ! scope="row" style="background:#b0e0e6;" | Saint George Fjord ! scope="row" | 🇬🇱 ! scope="row" style="background:#b0e0e6;" | Uummannaq Fjord ! scope="row" | 🇬🇱 ! scope="row" style="background:#b0e0e6;" | Sullorsuaq Strait ! scope="row" | 🇬🇱 ! scope="row" style="background:#b0e0e6;" | Disko Bay ! scope="row" | 🇬🇱 ! scope="row" style="background:#b0e0e6;" | Atlantic Ocean ! scope="row" | 🇨🇦 ! scope="row" style="background:#b0e0e6;" | Conception Bay ! scope="row" | 🇨🇦 ! scope="row" style="background:#b0e0e6;" | Conception Bay ! scope="row" | 🇨🇦 ! scope="row" style="background:#b0e0e6;" | Atlantic Ocean ! scope="row" | 🇫🇷 ! scope="row" | 🇧🇷 ! scope="row" style="background:#b0e0e6;" | Atlantic Ocean ! scope="row" style="background:#b0e0e6;" | Southern Ocean ! scope="row" | Antarctica