The girls' singles tournament of the 2010 US Open started on Sunday September 5, the seventh day of the main tournament. Heather Watson was the defending champion, but was no longer eligible to compete as a junior that year. Daria Gavrilova won this event, after beating her compatriot Yulia Putintseva in the final, 6–3, 6–2.

Seeds

• # 🇷🇺 Daria Gavrilova (champion) • # 🇭🇺 Tímea Babos (second round) • # 🇷🇺 Irina Khromacheva (second round) • # 🇺🇦 Elina Svitolina (third round) • # Monica Puig (quarterfinals) • # 🇨🇿 Karolína Plíšková (quarterfinals) • # 🇨🇿 Kristýna Plíšková (second round) • # 🇬🇧 Laura Robson (third round) • # 🇨🇦 Gabriela Dabrowski (third round) • # 🇸🇰 Jana Čepelová (second round) • # 🇧🇪 An-Sophie Mestach (first round) • # 🇨🇳 Zheng Saisai (first round) • # 🇨🇳 Tang Haochen (third round) • # 🇺🇸 Beatrice Capra (withdrew due to fatigue after playing three rounds in the women's singles event) • # 🇺🇸 Sloane Stephens (semifinals) • # 🇪🇸 María Teresa Torró Flor (first round)

Draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4