The 2010 Tennis Napoli Cup was a professional tennis tournament played on outdoor red clay courts. It was part of the 2010 ATP Challenger Tour. It took place in Naples, Italy between 29 March and 4 April 2010.

ATP entrants

Seeds

Other entrants

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following players received the lucky spots:

Champions

Singles

Rui Machado def. 🇦🇷 Federico del Bonis, 6–4, 6–4

Doubles

🇯🇲 Dustin Brown / 🇺🇸 Jesse Witten def. 🇮🇳 Rohan Bopanna / 🇵🇰 Aisam-ul-Haq Qureshi, 7–6(4), 7–5